Hadar busia-singleton biography of rory
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Characterization of a Melamino Nitroheterocycle as a Potential Lead for the Treatment of Human AfricanTrypanosomiasis
PubMed Central
Giordani, Federica; Buschini, Annamaria; Baliani, Alessandro; Kaiser, Marcel; Brun, Reto; Barrett, Michael P.; Pellacani, Claudia; Poli, Paola
2014-01-01
This paper reports an evaluation of a melamino nitroheterocycle, a potential lead for further development as an agent against human Africantrypanosomiasis (HAT). Studies on its efficacy, physicochemical and biopharmaceutical properties, and potential for toxicity are described. The compound previously had been shown to possess exceptional activity against Trypanosoma brucei in in vitro assays comparable to that of melarsoprol. Here, we demonstrate that the compound also was curative in the stringent acute mouse model T. brucei rhodesiense STIB 900 when given intraperitoneally at 40 mg/kg of body weight. Nevertheless, activity was only moderate when the oral route was used, and no cure was obtained when the compound was tested in a stage 2 rodent model of infection. Genotoxic profiling revealed that the compound induces DNA damage by a mechanism apparently independent from nitroreduction and involving the introduction of base pair substitutions (Ames test), possibly caused by oxidative damag
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Tchaikovsky: The Sleeping Beauty
Related papers
Christos Charakopoulos
Book of Abstract, 2023
Music and literature, the sister arts, emerged as a discrete area of research in the eighteenth century. Brown (1970) explored their relationship as a field of study and concluded that the two arts can be combined in their various genres. Calogero (2002) also claims that integrating music with children’s books enhances the ideas and themes implicit in both while improving basic understandings of language and story. In addition, music, as an integral part of children’s lives, has a unique and powerful ability to affect how children listeners react to a story and provide a subtext and omniscient commentary to the visual narrative (Schaefer, 1998). Therefore, blending music with literature can create a pleasing effect for the young reader/listener, and exploring the world of music through non-fiction picture books helps the children revisit even classical music works. Considering the above theoretical framework, this paper addresses the relationship of music, text, and image to engage young readers with Pyotr Ilyich Tchaikovsky’s famous ballets Swan Lake, The Nutcracker, and The Sleeping Beauty. Th
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Archives West Discovery Aid
General Line-up: Crim, Babcock, Pullen, Sigsworth, Railsback, Shoudy, Tibbals, Brinker, Humourist, Dean, Pol, McElmon, Tilley Utah Line-up: Peterson, Mortensen, Nelsen, Matesen, Nelsen, Chemist, Jamisen, Fenn, Engersoll, Madsen, Waingard
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Adamson, Herb; Barker, Elwood; Bowman, Desire W.; Brolinbroke, Bert; Service, Rudolph; Conroy, Maurice; Cooley, Walter; Croft, Jack; Archaeologist, James; Collector, Bert; Accumulator, Dave; Diplomat, S. R.; Hendricks, C.D.; Jeffs, Armond; Kirk, Harvey; Knowles, Educator B.; Leddingham, Clarence; Playwright, Claude; Maughn, Joseph; Gang