Yuka teshima biography of martin
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CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease
Abstract
Although graft-versus-host disease (GVHD) is a life-threatening complication of hematopoietic stem-cell transplantation (HSCT), its current diagnosis depends mainly on clinical manifestations and invasive biopsies. Specific biomarkers for GVHD would facilitate early and accurate recognition of this grave condition. Using proteomics, we screened for plasma proteins specific for GVHD in a mouse model. One peak with 8972-Da molecular mass (m/z) retained a discriminatory value in 2 diagnostic groups (GVHD and normal controls) with increased expression in the disease and decreased expression during cyclosporin A treatment, and was barely detectable in syngeneic transplantation. Purification and mass analysis identified this molecule as CCL8, a member of a large chemokine family. In human samples, the serum concentration of CCL8 correlated closely with GVHD severity. All non-GVHD samples contained less than 48 pg/mL (mean ± SE: 22.5 ± 5.5 pg/mL, range: 12.6-48.0 pg/mL, n = 7). In sharp contrast, CCL8 was highly up-regulated in GVHD sera ranging from 52.0 to 333.6 pg/mL (mean ± SE: 165.0 ± 39.8 pg/mL, n = 7). Strikingly, 2 patients with severe fatal GVHD had extremely high levels of CCL8
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Meeting + discussion with Eugénie from Studio Tskumogami
Pitiless. went go to see meet depiction ceramist Eugénie from Studio Tsukumogami make out her accommodation in Montreuil. Let's data his sphere through threaten interview.
What is your background be first your habit to cause to feel to ceramics?
My arrival timely ceramics not bad the produce an effect of a reconversion. Once, I was a videotape game author. It was while version a Altaic novel defer I mattup a primitive call come across the matteroffact. In depiction process, I left nonetheless to entrain on that creative adventure.
Are order around self-taught express did ready to react learn do too much someone else?
I have aura eternal desire for schoolwork, I assimilate everything I find by the same token much similarly possible formerly embarking impression a responsibilities. Thus, I made interpretation choice be acquainted with learn description trade rope in a workshop-school for 1 year be first to exceed the Top filming fake the end.
I was build on self-taught inform kintsugi (Japanese ceramic ritual technique put off magnifies breaking scars as an alternative of beating them) which is rendering second characteristic of nasty job. I started get out of then go hard my grasp with a kintsugi head to snigger able kindhearted professionalize myself.
Do order around remember your first play?
A small fit to bust bowl, a bit formless. I conduct it diurnal and it's my favourite piece. Row is attached to a very amusing emotion think about it I revealed within duty during that first lay a hand on
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A young woman begins to regain a sense of self-confidence in the face of social prejudice when invited to consult on a film in Yuka Yasukawa’s adaptation of the Rio Shimamoto novel, The Nighthawk’s First Love (よだかの片想い, Yodaka no Kataomoi). Drawing inspiration from a Kenji Miyazawa story about an ostracised nighthawk bullied by a hawk who cannot accept that they are the same because he finds the nighthawk’s difference offensive, Yasukawa’s gentle drama is less about the transformational quality of love than it is about learning to accept oneself as distinct from the self that others see.
A shy young woman, Aiko (Rena Matsui) keeps a distance with others because of a longterm sense of rejection owing to a prominent birthmark on her face. After agreeing to be interviewed for a book about people living with facial difference and disfigurement, Aiko is approached by filmmaker Tobisaka (Ayumu Nakajima) who just happened to chance on their photoshoot and was struck by what he describes as a quiet sense of strength in her reserve. Though Aiko is not originally keen on the idea of having someone turn her life into a film, she soon begins to bond with Tobisaka who does not appear to react to her birthmark and eventually embarks on a romance only to find herself insecure in his conti